Plotting haplotype-specific linkage disequilibrium patterns by extended haplotype homozygosity
نویسندگان
چکیده
منابع مشابه
Efficient mining of haplotype patterns for linkage disequilibrium mapping.
Effective identification of disease-causing gene locations can have significant impact on patient management decisions that will ultimately increase survival rates and improve the overall quality of health care. Linkage disequilibrium mapping is the process of finding disease gene locations through comparisons of haplotype frequencies between disease chromosomes and normal chromosomes. This wor...
متن کاملLinkage disequilibrium, haplotype evolution, and the coalescent
Linkage disequilibrium has become an important tool for fine-scale mapping. We argue that in order to understand the pattern of association between alleles at different loci, as well as DNA sequence polymorphism, it is useful first to consider the underlying genealogy of the chromosomes. The stochastic process known as the coalescent provides an extremely convenient way of modeling such genealo...
متن کاملThe trimmed-haplotype test for linkage disequilibrium.
Single-marker linkage-disequilibrium (LD) methods cannot fully describe disequilibrium in an entire chromosomal region surrounding a disease allele. With the advent of myriad tightly linked microsatellite markers, we have an opportunity to extend LD analysis from single markers to multiple-marker haplotypes. Haplotype analysis has increased statistical power to disclose the presence of a diseas...
متن کاملHomozygosity and linkage disequilibrium.
We illustrate how homozygosity of haplotypes can be used to measure the level of disequilibrium between two or more markers. An excess of either homozygosity or heterozygosity signals a departure from the gametic phase equilibrium: We describe the specific form of dependence that is associated with high (low) homozygosity and derive various linkage disequilibrium measures. They feature a clear ...
متن کاملLinkage disequilibrium sharing and haplotype-tagged SNP portability between populations.
The discovery of the block-like structure of linkage disequilibrium (LD) in human populations holds the promise of delineating the etiology of common diseases. However, understanding the magnitude, mechanism, and utility of between-population LD sharing is critical for future genome-wide association studies. In this study, substantial LD sharing between six non-African populations was observed,...
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ژورنال
عنوان ژورنال: Bioinformatics
سال: 2004
ISSN: 1367-4803,1460-2059
DOI: 10.1093/bioinformatics/btg481